Basic Information
VIS ID
TVIS44006237
Fusion event
HTLV-1-AKT1S1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50374446/49871189 (Hg38)
End
50374446/49871189 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
AKT1S1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-484 ; hsa-mir-185-5p ; hsa-mir-142-3p ; hsa-mir-139-3p ; hsa-mir-1587 ; hsa-mir-1908-5p ; hsa-mir-2467-3p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3134 ; hsa-mir-3173-3p ; hsa-mir-3202 ; hsa-mir-3620-5p ; hsa-mir-3652 ; hsa-mir-3677-3p ; hsa-mir-4281 ; hsa-mir-431-3p ; hsa-mir-432-3p ; hsa-mir-4417 ; hsa-mir-4430 ; hsa-mir-4440 ; hsa-mir-4449 ; hsa-mir-4450 ; hsa-mir-4492 ; hsa-mir-4498 ; hsa-mir-450a-1-3p ; hsa-mir-4533 ; hsa-mir-4656 ; hsa-mir-4675 ; hsa-mir-4695-5p ; hsa-mir-4706 ; hsa-mir-4741 ; hsa-mir-4746-5p ; hsa-mir-4749-5p ; hsa-mir-488-3p ; hsa-mir-5001-5p ; hsa-mir-542-5p ; hsa-mir-5681a ; hsa-mir-6087 ; hsa-mir-6089 ; hsa-mir-635 ; hsa-mir-663a ; hsa-mir-6716-5p ; hsa-mir-6730-5p ; hsa-mir-6731-5p ; hsa-mir-6774-5p ; hsa-mir-6787-5p ; hsa-mir-6788-5p ; hsa-mir-6829-5p ; hsa-mir-6857-5p ; hsa-mir-6871-5p ; hsa-mir-6878-5p ; hsa-mir-6891-5p ; hsa-mir-7150 ; hsa-mir-762 ; hsa-mir-8085
Nearest miRNA
hsa-mir-10395/Upstream/16538; hsa-let-7e/Downstream/16986;
Nearest TSS
ENST00000633603/Upstream/3280; ENST00000598789/Downstream/2611;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1049, chr19-CpG: 26/Downstream/1910
Upstream sequence
AGGGTGAGGAGGACCCACCTAGGCCAGCAGAGCCCAGCCCAGGAGCTTCAAACAGGGGTTGCTACAAGGGGTGAACAGGGGACCAGGGGGTGGGACAAAT
Downstream sequence
TCTGCAAAGGGCTAGGAATGTGCAGGGTGGGGAtgggaggtgatctgaaccctccaagcctcagtttctccactggagggcatgccaaaacacctgtgcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate