Basic Information
VIS ID
TVIS44006253
Fusion event
HTLV-1-UBE2D1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
60111963/58352203 (Hg38)
End
60111963/58352203 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
UBE2D1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-188-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-513a-5p ; hsa-mir-409-3p ; hsa-mir-653-5p ; hsa-mir-4699-3p ; hsa-mir-219a-1-3p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-548j-5p ; hsa-mir-548n ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-3148 ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548ay-5p ; hsa-mir-548bb-5p ; hsa-mir-489-3p ; hsa-mir-571 ; hsa-mir-4676-3p ; hsa-mir-892c-3p ; hsa-mir-452-5p ; hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-7158-5p ; hsa-mir-33a-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-1265/Upstream/1047644; hsa-mir-107/Downstream/5020754;
Nearest TSS
ENST00000439456/Upstream/17224; ENST00000473824/Downstream/12253;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/16657, chr10-CpG: 60/Downstream/32760
Upstream sequence
CTGGGTTTCACATTTCTTTTTTTTCTTTCCATTTTCAACACATTGTCACAGTAGCTAAAGGTGAAATAAGTACTCTTGGTCCCATTCAGATGCCAAACAC
Downstream sequence
CATCACTTTTGCTTCCACATCAAAAGTGGAAGCACTTTTGTTTGCCTGAGACAGTGATGATATGCTAAGTTAGGTTTAAAGGATATGTTTATTTCCTATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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