Basic Information
VIS ID
TVIS44006258
Fusion event
HTLV-1-PRMT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
20447346/20425800 (Hg38)
End
20447346/20425800 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PRMT3
miRNAs that regulate target gene
hsa-mir-361-3p ; hsa-mir-106b-5p ; hsa-mir-1260b ; hsa-mir-5591-3p ; hsa-mir-5698 ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-564 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-5693 ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-5704 ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4495 ; hsa-mir-1295b-3p ; hsa-mir-15a-3p ; hsa-mir-4717-5p
Nearest miRNA
hsa-mir-210/Upstream/665717; hsa-let-7a-2/Downstream/2993305;
Nearest TSS
ENST00000527297/Upstream/20354; ENST00000298923/Downstream/173600;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/37565, chr11-CpG: 123/Downstream/170851
Upstream sequence
actctaatatataatgaaagaaagaaaatcagtggttgcttgtggatggggagattttctgggatgggcactaatctttgggggaagaggaaatgttcta
Downstream sequence
tatattgattgtggtggtcaacaaagtatctgtttttcggaatttaacaaaactaccctaaaatgaatgcactgaattgtttgtaaataatacccaatga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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