Basic Information
VIS ID
TVIS44006259
Fusion event
HTLV-1-MTCH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
47626848/47605296 (Hg38)
End
47626848/47605296 (Hg38)
Orient
-
Location type
Intronic
Target gene
MTCH2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-423-5p ; hsa-mir-484 ; hsa-mir-30c-5p ; hsa-let-7e-5p ; hsa-mir-135b-5p
Nearest miRNA
hsa-mir-129-2/Upstream/204254; hsa-let-7a-2/Downstream/491486;
Nearest TSS
ENST00000527297/Upstream/10637; ENST00000526550/Downstream/24059;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/10793, chr11-CpG: 63/Downstream/36729
Nearby gene
C1QTNF4(-10887) ;
Upstream sequence
ggattacaggtgtgagccaccgtgcccggcTGTCTCCCATATTTTTCACTGTTTCACCCCTTTGTAACTAAAATAACAAGAGGTGGGGAGAGCCACTATC
Downstream sequence
TTTTTAAGCAGCTGCTCCATTCCTACCGGTTTCtattcaacctgagatcagctgcaagcccttagcctttttctcaggcacctctggcaaaccaaacttc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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