Basic Information
VIS ID
TVIS44006266
Fusion event
HTLV-1-NUP37 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
102473565/102079787 (Hg38)
End
102473565/102079787 (Hg38)
Orient
-
Location type
Intronic
Target gene
NUP37
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-10a-5p ; hsa-mir-3915 ; hsa-mir-3928-3p ; hsa-mir-1200 ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-6832-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3161 ; hsa-mir-580-3p ; hsa-mir-4753-3p ; hsa-mir-670-5p ; hsa-mir-4669 ; hsa-mir-3657 ; hsa-mir-4251 ; hsa-mir-130b-5p ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-3919 ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-3925-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1277-5p ; hsa-mir-548c-3p ; hsa-mir-5582-3p ; hsa-mir-4773
Nearest miRNA
hsa-let-7i/Upstream/1889838; hsa-mir-1178/Downstream/1850638;
Nearest TSS
ENST00000382841/Upstream/2787; ENST00000537257/Downstream/6068;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/17582, chr12-CpG: 28/Downstream/40103
Upstream sequence
ctagccagcactacattactgtgcttggggatgattttacacagtaaaattttacacagtaaaattacccacaaaaagtacaaaaatgttaaaaatgtgg
Downstream sequence
cactaaactgacgaggaaaagacacatatttacagtatgaaagctaaaataagaagccagagttcaccttgttcaattttaggtgagcaagtgcacataa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate