Basic Information
VIS ID
TVIS44006269
Fusion event
HTLV-1-N4BP2L2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
33111065/32536928 (Hg38)
End
33111065/32536928 (Hg38)
Orient
+
Location type
Exonic
Target gene
N4BP2L2
miRNAs that regulate target gene
hsa-mir-455-3p ; hsa-mir-484 ; hsa-mir-3149 ; hsa-mir-29a-5p ; hsa-mir-500b-3p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-3152-3p ; hsa-mir-4694-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-3934-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-449b-3p ; hsa-mir-552-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-2276/Upstream/8374424; hsa-mir-1267/Downstream/7127106;
Nearest TSS
ENST00000623511/Upstream/545; ENST00000466078/Downstream/99;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/109188, chr13-CpG: 138/Downstream/49219
Upstream sequence
AACTATGTCCTCTGACATCAATGATGGTCACAGGGACCCAATCATTTCCAGTTTTCTCTTGGATTCTGTGAAAATCAGCATTACTATGATTGTGAAAAAC
Downstream sequence
ATACGACTCTGTGGTTGACTTCAATTTTTTACAGCGTGGCTCACTCGTTACTTCTTCTCTAGGTCCCAAGAATTTACCTTCAATTTCACCATAAGACATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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