Basic Information
VIS ID
TVIS44006278
Fusion event
HTLV-1-MEIS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
37374903/37082702 (Hg38)
End
37374903/37082702 (Hg38)
Orient
-
Location type
Intronic
Target gene
MEIS2
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1233-1/Upstream/109801; hsa-mir-10393/Downstream/4608883;
Nearest TSS
ENST00000557528/Upstream/178635; ENST00000559509/Downstream/11327;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/193990, chr15-CpG: 27/Downstream/15272
Upstream sequence
aaacagtatataTTATATAGGTGCAAGTTGCAAGTTCTTCCATAATTTGCCGTCTGATATGATTCATCGCTGTGTTAGTTTCAATTTGCTTAAACCTAGA
Downstream sequence
TTCTAATTTGGACCCATTCACAAATGAATGGCATCCTAGAAAGGACATTTTTCTAGACTCTTCTAGAACCTCAGAAATCCAAAATTCCTAGTCAGAAGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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