Basic Information
VIS ID
TVIS44006286
Fusion event
HTLV-1-GNAL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
11879081/11879082 (Hg38)
End
11879081/11879082 (Hg38)
Orient
-
Location type
Intronic
Target gene
GNAL
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-99a-5p ; hsa-mir-16-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-6792-5p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6838-5p ; hsa-mir-759 ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-489-3p ; hsa-mir-129-5p ; hsa-mir-6878-3p ; hsa-mir-6735-3p ; hsa-mir-329-5p ; hsa-mir-4761-5p
Nearest miRNA
hsa-mir-3976/Upstream/224141; hsa-mir-1-2/Downstream/1580865;
Nearest TSS
ENST00000575820/Upstream/6781; ENST00000609611/Downstream/6039;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/26959, chr18-CpG: 109/Downstream/29141
Upstream sequence
cattaggagatacacctaatgtaaatgacgagttaatgggtgcagcacaccaacatggcacatgtatacatatgtaacaaacctgcacgttgtgcacatg
Downstream sequence
tatcctagaacttacagtataataaaatatatatatattaaaaatatatatatataaCCTACTCATTTTAGTGTCCATAAGTTTTTTTTTTAATGCTCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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