Basic Information
VIS ID
TVIS44006291
Fusion event
HTLV-1-ASXL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
31159486/33579522 (Hg38)
End
31159486/33579522 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
ASXL3
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-26b-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4533 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6783-5p ; hsa-mir-4779 ; hsa-mir-6510-5p ; hsa-mir-3120-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-1305 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-498 ; hsa-mir-4465 ; hsa-mir-26a-5p ; hsa-mir-6715b-3p ; hsa-mir-1297 ; hsa-mir-676-5p ; hsa-mir-7844-5p ; hsa-mir-708-3p
Nearest miRNA
hsa-mir-1-2/Upstream/3280562; hsa-mir-122/Downstream/2012215;
Nearest TSS
ENST00000575820/Upstream/609; ENST00000647014/Downstream/26064;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/499, chr18-CpG: 45/Downstream/579561
Upstream sequence
GTACAGCTAGGTGTATTTTACTGCTGGCTTCCTGGGCGGTGTTACTTGGCTGCTTTTCCTTTTCTTTAACCTTTCGGAGCTTACGTTTTAATCATCGAAA
Downstream sequence
GAATGTCTCTATAGAAATGCCGGTTGGCAGAGGGGCGTCGGCGTCTTTGGTTTGATGCATGTATATGTGTGGGtttttcttttctttctttcttttttct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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