Basic Information
VIS ID
TVIS44006295
Fusion event
HTLV-1-chr19 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
56832769/56321400 (Hg38)
End
56832769/56321400 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LOC112268243 ; LOC729999 ; ZSCAN5A
miRNAs that regulate target gene
hsa-mir-218-5p
Nearest miRNA
hsa-let-7e/Upstream/933158; hsa-mir-10394/Downstream/2013288;
Nearest TSS
ENST00000633603/Upstream/5801; ENST00000589671/Downstream/43597;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5983, chr19-CpG: 35/Downstream/17888
Nearby gene
ZNF542P(No orient, 46699)
Upstream sequence
GCCCATCACTGGTCAAGAAGTCCCATGCCCTCTGGGCTGTAATAACCAGGCATCACAATGTGGACACCAGCAGTTGGCTGGCAGATAGCTGCAGCATCCT
Downstream sequence
TATCATCTATTTTGCACACAGAGTCTGTGAAATGTCCAACGGCATTGATAACACACTTGGCTTTCATGTCAAATTCCTGCCCTGTGAGGACATCCTTGCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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