Basic Information
VIS ID
TVIS44006298
Fusion event
HTLV-1-SLC8A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
40499036/40271896 (Hg38)
End
40499036/40271896 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC8A1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-1273e ; hsa-mir-3924 ; hsa-mir-590-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-410-3p ; hsa-mir-4699-3p ; hsa-mir-4683 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-494-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-6847-5p ; hsa-mir-512-3p ; hsa-mir-6888-5p ; hsa-mir-5693 ; hsa-mir-8057 ; hsa-mir-4423-3p ; hsa-mir-760 ; hsa-mir-6822-3p ; hsa-mir-3135a ; hsa-mir-4766-5p ; hsa-mir-146a-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-4775 ; hsa-mir-4668-3p ; hsa-mir-1305 ; hsa-mir-599 ; hsa-mir-3978 ; hsa-mir-3161 ; hsa-mir-6124 ; hsa-mir-4282 ; hsa-mir-3148 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-185-5p
Nearest miRNA
hsa-mir-1301/Upstream/4800410; hsa-mir-10b/Downstream/7105779;
Nearest TSS
ENST00000437798/Upstream/20473; ENST00000420187/Downstream/158375;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/492573, chr2-CpG: 16/Downstream/179441
Upstream sequence
CCACGGATTGACTCATTTTCTTTCCGGAGTCAACTTTTACTGATGACCAAAGTTTATTtttattattttatttatttatttttttttagagtcagggtct
Downstream sequence
cactctgttgcccgggctggaatgcagtggaaccgtcatagctcactgcagcctcgatgtcttgggctcaagcaatcctcccaccttagcctgctgagta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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