Basic Information
VIS ID
TVIS44006300
Fusion event
HTLV-1-CTNNA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
80179753/79952627 (Hg38)
End
80179753/79952627 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CTNNA2
Nearest miRNA
hsa-mir-1285-2/Upstream/86044; hsa-mir-10b/Downstream/5830973;
Nearest TSS
ENST00000437798/Upstream/254781; ENST00000493024/Downstream/77924;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/439510, chr2-CpG: 101/Downstream/349925
Nearest cancer related gene
CTNNA2(TSG, No orient, 0)
Upstream sequence
agagttgttatAAAAAATGAGGTAAAAAATTTTATGAAAGACATTTTGAAAATGTGAATTTTACTTTTCTAGCAAAAGAAAAGATATAAAACAATAATAC
Downstream sequence
AAGAACGAAATTGAATCCTAGTCTGGGAATATTCTGAGGACTGGCAGTTTTTGTGGTGTTTCTTGTTATGTGAAACTTGAGAACAGGgctggcaaactat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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