Basic Information
VIS ID
TVIS44006302
Fusion event
HTLV-1-BAZ2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
160402478/159545967 (Hg38)
End
160402478/159545967 (Hg38)
Orient
-
Location type
Intronic
Target gene
BAZ2B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-424-5p ; hsa-mir-487a-3p ; hsa-mir-377-5p ; hsa-mir-485-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-4327 ; hsa-mir-500a-3p ; hsa-mir-6499-3p ; hsa-mir-767-5p ; hsa-mir-4537 ; hsa-mir-5186 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-25-3p ; hsa-mir-508-5p ; hsa-mir-3145-5p ; hsa-mir-599 ; hsa-mir-4276 ; hsa-mir-506-5p ; hsa-mir-892c-5p ; hsa-mir-302f ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-6771-5p ; hsa-mir-425-3p ; hsa-mir-7977 ; hsa-mir-3178 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4743-5p ; hsa-mir-6499-5p ; hsa-mir-6746-5p ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-128-1/Upstream/359066; hsa-mir-10b/Downstream/861843;
Nearest TSS
ENST00000437798/Upstream/29308; ENST00000418474/Downstream/9897;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/258911, chr2-CpG: 60/Downstream/69610
Upstream sequence
CGACTGACTTATTATATTGTTACTGAAATATAGAAAAATACAACTACGGATAAGGATAAACTATTCCTCTTGCTTCCAGATCTTATTTCAAATACAATAC
Downstream sequence
CAAAACAATTTCCAAATATGCACATAAAAGCTATGAATAGCACATTTCAAGTTAGTATCATACAATGTTTTTGTGAAAATGAATCATTATAGTCAACATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate