Basic Information
VIS ID
TVIS44006307
Fusion event
HTLV-1-BCL2L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
End
30305942/31718139 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-491-5p ; hsa-let-7g-5p ; hsa-let-7c-5p ; hsa-mir-122-5p ; hsa-mir-30a-5p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-133a-3p ; hsa-mir-218-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1287-3p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-198 ; hsa-mir-4710 ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-7854-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-455-3p ; hsa-mir-4779 ; hsa-mir-4257 ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-4749-3p ; hsa-mir-587 ; hsa-mir-4313 ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-361-3p ; hsa-mir-4691-3p ; hsa-mir-449b-3p ; hsa-mir-133b ; hsa-mir-608 ; hsa-mir-34a-5p ; hsa-mir-326 ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-1207-5p ; hsa-mir-1233-5p ; hsa-mir-1251-5p ; hsa-mir-1265 ; hsa-mir-1273h-5p ; hsa-mir-1289 ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-184 ; hsa-mir-1909-3p ; hsa-mir-1915-5p ; hsa-mir-1972 ; hsa-mir-197-5p ; hsa-mir-298 ; hsa-mir-30b-3p ; hsa-mir-3120-3p ; hsa-mir-3132 ; hsa-mir-3154 ; hsa-mir-3165 ; hsa-mir-3179 ; hsa-mir-3605-5p ; hsa-mir-3619-3p ; hsa-mir-363-5p ; hsa-mir-3652 ; hsa-mir-3671 ; hsa-mir-3688-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-3690 ; hsa-mir-371a-5p ; hsa-mir-371b-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-3919 ; hsa-mir-3940-3p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-4430 ; hsa-mir-4436b-3p ; hsa-mir-4451 ; hsa-mir-4467 ; hsa-mir-4468 ; hsa-mir-4474-5p ; hsa-mir-4505 ; hsa-mir-4532 ; hsa-mir-4632-5p ; hsa-mir-4650-5p ; hsa-mir-4651 ; hsa-mir-4685-5p ; hsa-mir-4709-3p ; hsa-mir-4711-5p ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4763-3p ; hsa-mir-4764-5p ; hsa-mir-4776-5p ; hsa-mir-4804-5p ; hsa-mir-502-5p ; hsa-mir-5197-3p ; hsa-mir-5586-3p ; hsa-mir-5684 ; hsa-mir-5787 ; hsa-mir-6081 ; hsa-mir-616-5p ; hsa-mir-6721-5p ; hsa-mir-6722-3p ; hsa-mir-6732-5p ; hsa-mir-6735-5p ; hsa-mir-6745 ; hsa-mir-6752-5p ; hsa-mir-6753-5p ; hsa-mir-6755-5p ; hsa-mir-6756-5p ; hsa-mir-6758-5p ; hsa-mir-6766-5p ; hsa-mir-6770-3p ; hsa-mir-6770-5p ; hsa-mir-6778-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6791-5p ; hsa-mir-6799-5p ; hsa-mir-6825-5p ; hsa-mir-6837-5p ; hsa-mir-6838-3p ; hsa-mir-6841-3p ; hsa-mir-6842-3p ; hsa-mir-6842-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-6879-5p ; hsa-mir-6880-5p ; hsa-mir-6883-5p ; hsa-mir-6894-5p ; hsa-mir-7106-5p ; hsa-mir-7110-5p ; hsa-mir-7152-3p ; hsa-mir-7843-5p ; hsa-mir-8071 ; hsa-mir-922
Nearest miRNA
hsa-mir-103a-2/Upstream/110899; hsa-mir-1-1/Downstream/519656;
Nearest cancer related gene
BCL2L1(OG, No orient, 0)
Upstream sequence
CCATTCATTAAAGGGTTTCCACCCTACAATTATGGCAGGAGAAGGGCTTTTGTGCTAGATCCTTTACTCGAGTCAAGCTATGGCAGCTGGCTATCATTAT
Downstream sequence
TCCATTTTACAGGCGGGAGAGACAGATGGACAAGACAGCCGAACAGGTTCAGCATTTCATCAGGTGACTCCAGGCAGGCAGTAATCTGGCTAAGGGTCTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate