Basic Information
VIS ID
TVIS44006310
Fusion event
HTLV-1-PPARG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
12437131/12395632 (Hg38)
End
12437131/12395632 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPARG
miRNAs that regulate target gene
hsa-mir-20b-5p ; hsa-mir-27b-3p ; hsa-mir-138-5p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-20a-5p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-27a-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12127/Upstream/2001070; hsa-let-7g/Downstream/3100607;
Nearest TSS
ENST00000440867/Upstream/15926; ENST00000490981/Downstream/88800;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/106798, chr3-CpG: 61/Downstream/88618
Nearest cancer related gene
PPARG(OG, No orient, 0)
Upstream sequence
GACACATCGTCTACATGTTGTAGAAGAACATAGTTTCAGAATTCTTCCAGTTAGAAACATAGTTTCTCAAATATTCACTTTCAGCATTGGGTAGAAAAAG
Downstream sequence
TACCCAGGTGATGGACTGATTGATATGCTTCAGAAATATGTTTTTTCCTGCAAGTAATGAAAATAAACACACGTTCTTAATTATTTTGGTCATTTAACAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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