Basic Information
VIS ID
TVIS44006316
Fusion event
HTLV-1-PROS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
93692281/93973437 (Hg38)
End
93692281/93973437 (Hg38)
Orient
-
Location type
Intronic
Target gene
PROS1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-let-7g/Upstream/6747160; hsa-mir-12124/Downstream/2386527;
Nearest TSS
ENST00000440867/Upstream/14683; ENST00000478400/Downstream/202;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4858480, chr3-CpG: 39/Downstream/273
Upstream sequence
GCTAGAATCTGCTCATCCTAGTTCTCTGACTGGGAACTTCAGCTTTGAAGGGAAATGGGCAGGTGTTCTCATCCCTCCATTGATACTTAGTGTCATCTAG
Downstream sequence
GTTCTTAGATCTGTCCTGTAGGCAATACATTCTCGCAACTGTGCAAATAGTGATCCTGCCCCACCATTGCACTGCCTGCTCTATCCACGGCTGTTTCCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate