Basic Information
VIS ID
TVIS44006323
Fusion event
HTLV-1-USP13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37/hg19
Start
179371618/179653830 (Hg38)
End
179371618/179653830 (Hg38)
Orient
+
Location type
Intronic
Target gene
USP13
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-1468-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-3163 ; hsa-mir-548x-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548aj-5p ; hsa-mir-4671-3p ; hsa-mir-548aw ; hsa-mir-6080 ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-1305 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-4778-3p ; hsa-mir-539-3p
Nearest miRNA
hsa-let-7g/Upstream/3138679; hsa-mir-1224/Downstream/4232970;
Nearest TSS
ENST00000440867/Upstream/137; ENST00000497155/Downstream/67734;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/69, chr3-CpG: 96/Downstream/382902
Upstream sequence
CGGGGCAGAGCGCAGGGCGGGTAGGTGGACGGGATGATCCCCCCACACCCCGGGACACACACAGCCCTTCTTTTTCTGGGACCACTTGCTTTGCTCAGGG
Downstream sequence
ATCCCCACTTCTGGACAATTCTGATTTGCTCTCTGAGCTTTTCTTCCACCAGTTCCCATTTCACCCCACTCCTTTTCTTGTCTTTAGAATGTCAGggcca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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