Basic Information
VIS ID
TVIS44006338
Fusion event
HTLV-1-LRBA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
151854880/150933728 (Hg38)
End
151854880/150933728 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRBA
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-769-5p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-12113/Upstream/3151060; hsa-mir-1305/Downstream/1555599;
Nearest TSS
ENST00000502981/Upstream/84191; ENST00000503002/Downstream/81539;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/349795, chr4-CpG: 89/Downstream/81773
Upstream sequence
AAAAAAAGATTTTAGTACATACACTTTTGAACAATTTGAATTTTGTGCCATGAACACATATTACTTATTTCAAAAAAAACAATTTAAAAAGAAGCAAATG
Downstream sequence
CAgccaggtagggtggcttatgcctgtaatcccagcactttgggaaaccgagagagcagatcagttgcactcagagagttcaagaccagcctggggtctt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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