Basic Information
VIS ID
TVIS44006341
Fusion event
HTLV-1-CENPK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64826196/65530369 (Hg38)
End
64826196/65530369 (Hg38)
Orient
-
Location type
Intronic
Target gene
CENPK
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-450b-5p ; hsa-mir-4528 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-6759-3p ; hsa-mir-6734-3p ; hsa-mir-3646 ; hsa-mir-1252-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-106a-3p ; hsa-mir-885-3p ; hsa-mir-5589-3p ; hsa-mir-95-5p ; hsa-mir-3662
Nearest miRNA
hsa-mir-10397/Upstream/5826666; hsa-mir-103a-1/Downstream/6639098;
Nearest TSS
ENST00000502646/Upstream/583; ENST00000508982/Downstream/12457;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/426980, chr5-CpG: 43/Downstream/32579
Upstream sequence
GACGTTTACTCCAGCAatggtcaagtgtcataaagaaaaaaaaaatcaaaataaaagtaaaggtatgaagagcaagaaatagatgttttaggtagtatga
Downstream sequence
tatggaaagacttctctgatcaggtaacatttaaataacagagaaagaagacaaaggaaaacattatgttactctctagcaaaagaatgttccagggaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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