Basic Information
VIS ID
TVIS44006349
Fusion event
HTLV-1-L3MBTL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
130343322/130022177 (Hg38)
End
130343322/130022177 (Hg38)
Orient
-
Location type
Intronic
Target gene
L3MBTL3
Nearest miRNA
hsa-mir-10398/Upstream/3537464; hsa-mir-1202/Downstream/1769995;
Nearest TSS
ENST00000381078/Upstream/1620; ENST00000531313/Downstream/32910;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/872, chr6-CpG: 134/Downstream/343092
Upstream sequence
TTTTATTTTAATTTACCGAGTGGCATGGTGTAAAATTATGCCTAAGTGATTCAGAATGTAAGCTTCTTAACTGGGGATGGTGGATTTGAAGGTTTCTTTT
Downstream sequence
TGATGACAGTGTTTTGATTTTACCTTCCCTCTCTTTAAACCAATGCTAGAACCCTTAGGAGAAATCTTGAGAGTGGACAGCAATTGTGAAGATCGCCAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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