Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene557683735579354455862789557743415577557755815581
Basic Information
VIS ID
TVIS44006352
Fusion event
HTLV-1-SEPTIN14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55883274/55815581 (Hg38)
End
55883274/55815581 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
SEPTIN14
miRNAs that regulate target gene
hsa-mir-5089-5p ; hsa-mir-6842-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6778-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-6814-5p ; hsa-mir-150-5p ; hsa-mir-6504-3p ; hsa-mir-4465 ; hsa-mir-4279 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6784-5p ; hsa-mir-6513-3p ; hsa-mir-8062 ; hsa-mir-129-5p ; hsa-mir-1304-5p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-25-5p ; hsa-mir-3197 ; hsa-mir-3655 ; hsa-mir-500b-3p ; hsa-mir-5691 ; hsa-mir-6087 ; hsa-mir-6765-5p ; hsa-mir-6805-3p ; hsa-mir-6879-3p ; hsa-mir-6885-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-1183/Upstream/10933781; hsa-mir-10399/Downstream/1140204;
Nearest TSS
ENST00000635602/Upstream/221804; ENST00000484120/Downstream/47174;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/74273, chr7-CpG: 41/Downstream/71661
Upstream sequence
ccaaagaagacatacaaatgtcttcttttgtcttattgataataactgttttaacatgtgtgaagtaactgctcattgtgggtttTTTTaaatgccaaac
Downstream sequence
aagcaaatgaaaaggtgctcaatatcactgattaccagagaaaggcaaataaaaactacaatgagatataatctcaccccagttaaaaaagcttttatcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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