Basic Information
VIS ID
TVIS44006357
Fusion event
HTLV-1-AGBL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
134757150/135072399 (Hg38)
End
134757150/135072399 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGBL3
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-5704 ; hsa-mir-330-3p ; hsa-mir-1295b-3p ; hsa-mir-15a-3p ; hsa-mir-4717-5p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-10525/Upstream/1781411; hsa-mir-10399/Downstream/134595;
Nearest TSS
ENST00000635602/Upstream/85795; ENST00000466307/Downstream/75673;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/85400, chr7-CpG: 84/Downstream/97824
Upstream sequence
tttcacactgttggtgggagtgtaaactagttcaaccattgtggaagtcagtgtggcaattcctcagggatccagaactagaaataccatttgacccagc
Downstream sequence
cttcccattactgggtatatacccagaggattataaaacatgctgctataaagacacatgcacatgtatgtttattgcggcactattcacaacagcaaag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate