Basic Information
VIS ID
TVIS44006358
Fusion event
HTLV-1-TNKS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
9462727/9605217 (Hg38)
End
9462727/9605217 (Hg38)
Orient
+
Location type
Intronic
Target gene
TNKS
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-324-3p ; hsa-mir-324-5p ; hsa-mir-142-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4693-5p ; hsa-mir-3607-3p ; hsa-mir-1183 ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-3674/Upstream/556699; hsa-mir-10400/Downstream/136455;
Nearest TSS
ENST00000518652/Upstream/30210; ENST00000521039/Downstream/10073;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/48634, chr8-CpG: 60/Downstream/293450
Upstream sequence
aaaataatacaacagttttgtttactccaaaaagttgtctggtgcccatctgcagtcaatttttcttcttgtcagccatccccagtcaacaatgatctat
Downstream sequence
tttctgacattatagattaattttcccttctagaaatatgttcttgtgtgtctggcttcttttgctcatcatgttttgaagttttggagatttcatccct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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