Basic Information
VIS ID
TVIS44006362
Fusion event
HTLV-1-ATP6V0D2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87146078/86133849 (Hg38)
End
87146078/86133849 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP6V0D2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-665 ; hsa-mir-2467-3p ; hsa-mir-1273e ; hsa-mir-6771-5p ; hsa-mir-7160-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-5690 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p
Nearest miRNA
hsa-mir-12123/Upstream/5892376; hsa-mir-10400/Downstream/5071636;
Nearest TSS
ENST00000518652/Upstream/35012; ENST00000523112/Downstream/20357;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/64032, chr8-CpG: 100/Downstream/208466
Upstream sequence
gggtcagagagggctgagcgggaagctgggcctttgaccacctcccagcagtaatgagccctctttttagccttggtgtcaatagaggccacacacagag
Downstream sequence
tagtaataaatcccagaaggagaggagaaaaaaagaaaggttgaaaaagtattcaaagaaataatggctgaaaattccccccatttggcaaaagacacac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate