Basic Information
VIS ID
TVIS44006373
Fusion event
HTLV-1-THOC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
122792595/123658744 (Hg38)
End
122792595/123658744 (Hg38)
Orient
+
Location type
Intronic
Target gene
THOC2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-34a-5p ; hsa-mir-21-5p ; hsa-mir-1180-3p ; hsa-mir-877-3p ; hsa-mir-183-5p ; hsa-mir-3591-5p ; hsa-mir-3156-3p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-3140-3p ; hsa-mir-7106-3p ; hsa-mir-6831-3p ; hsa-mir-532-3p ; hsa-mir-4301 ; hsa-mir-1273g-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-let-7f-2/Upstream/2287691; hsa-mir-105-1/Downstream/10510634;
Nearest TSS
ENST00000429181/Upstream/32108; ENST00000422098/Downstream/38943;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/473447, chrX-CpG: 75/Downstream/73605
Upstream sequence
aggcaaaaccacgcagacaatgaaaagctcagtggttgccaggggttgtgaggagagagggataaatgagcagagcacagaggattttttagggcagtga
Downstream sequence
taatattctatacatttgatgagatccctagtatgtacaacacaaagcaaatcctgatgtaaactatggactttgggtgatgtgtcaatgtggattcatc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate