Basic Information
VIS ID
TVIS44006379
Fusion event
HTLV-1-ARCN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
118470075/118599360 (Hg38)
End
118470075/118599360 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
ARCN1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-361-5p ; hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-let-7b-5p ; hsa-mir-652-3p ; hsa-mir-193b-3p ; hsa-mir-30c-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-let-7e-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-1185-1-3p ; hsa-mir-770-5p ; hsa-mir-1185-2-3p
Nearest miRNA
hsa-mir-10392/Upstream/5149272; hsa-let-7a-2/Downstream/44640;
Nearest TSS
ENST00000527297/Upstream/26390; ENST00000525427/Downstream/7080;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/26444, chr11-CpG: 276/Downstream/8232
Upstream sequence
ttttgtatttttagtaaagacggtatttcaccatgttggccaggctggtctcaaactcttgacctcgtgatccagccacctcggcctcccaaagtgctag
Downstream sequence
gattacaggcgcgagtcaccgcgctcggccCGGATCATTATTTTTTAACTCATCATTCTTCCAGtttttattgttgttgttgttttgagacggagtcttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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