Basic Information
VIS ID
TVIS44006391
Fusion event
HTLV-1-CTCF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67604357/67570454 (Hg38)
End
67604357/67570454 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
CTCF
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-mir-1229-3p ; hsa-mir-615-3p ; hsa-let-7b-5p ; hsa-mir-221-3p ; hsa-mir-3662 ; hsa-mir-567 ; hsa-mir-4798-5p ; hsa-mir-6740-5p ; hsa-mir-8088 ; hsa-mir-3140-3p ; hsa-mir-4307 ; hsa-mir-1322
Nearest miRNA
hsa-mir-1225/Upstream/368059; hsa-mir-11401/Downstream/662972;
Nearest TSS
ENST00000527434/Upstream/2563; ENST00000566078/Downstream/287;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6803, chr16-CpG: 54/Downstream/74235
Nearest cancer related gene
CTCF(TSG, No orient, 0)
Upstream sequence
caggcgtaagccactgcgcccagccAATAATTAATTTTTTGGTAGTTTGAATATGTGTGCCATTATTTGGTTGCAATATTGCAGTGGAGTGttttgtttt
Downstream sequence
gtttttttttttgagacggagtctcgctctgtcgcccaggctggagtgccgtggtgcgatctcggctcactgcatgctctgcctcccaggtttgcaccat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate