Basic Information
VIS ID
TVIS44006411
Fusion event
HTLV-1-IFFO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
19267876/18941382 (Hg38)
End
19267876/18941382 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
IFFO2
miRNAs that regulate target gene
hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-4776-3p ; hsa-mir-192-3p ; hsa-mir-548s ; hsa-mir-6883-5p ; hsa-mir-3945 ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-3926 ; hsa-mir-4641 ; hsa-mir-3616-3p ; hsa-mir-3651 ; hsa-mir-103b ; hsa-mir-4761-3p ; hsa-mir-574-5p ; hsa-mir-513b-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5003-5p ; hsa-mir-205-3p ; hsa-mir-1224-5p ; hsa-mir-184 ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-323a-3p ; hsa-mir-3665 ; hsa-mir-4506 ; hsa-mir-4648 ; hsa-mir-4751 ; hsa-mir-497-3p ; hsa-mir-5004-5p ; hsa-mir-6081 ; hsa-mir-6089 ; hsa-mir-92b-5p ; hsa-mir-1827 ; hsa-mir-185-5p ; hsa-mir-3165 ; hsa-mir-4306 ; hsa-mir-4514 ; hsa-mir-4644 ; hsa-mir-4692 ; hsa-mir-4743-5p ; hsa-mir-5192 ; hsa-mir-6808-5p ; hsa-mir-6880-5p ; hsa-mir-6893-5p ; hsa-mir-711 ; hsa-mir-8071 ; hsa-mir-940
Nearest miRNA
hsa-mir-12136/Upstream/44234; hsa-mir-101-1/Downstream/1692297;
Nearest TSS
ENST00000473358/Upstream/20261; ENST00000437898/Downstream/14316;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/38242, chr1-CpG: 182/Downstream/14072
Upstream sequence
GCCAAGCCTCCCAAGGCTTCTCTGTTTGGGCCCTGCAATCCCTTCCACCTCGTTTCCCACCTTGGGGGGTGATGTGCTTGGACTTAAACCGGGCAGAAGC
Downstream sequence
TACAAAGCAGCCTTTGTCTCACAGATGAAACCCTAAACCAGCTGCCCTGACGTCAACTCTGGAAAAACAATGCCAAGCCAGCCTTCAACGTCACTCCTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate