Basic Information
VIS ID
TVIS44006441
Fusion event
HTLV-1-ROBO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
79001839/78952689 (Hg38)
End
79001839/78952689 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROBO1
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-218-5p ; hsa-mir-423-3p ; hsa-mir-25-3p ; hsa-mir-6835-3p ; hsa-mir-146a-5p ; hsa-mir-377-3p ; hsa-mir-1185-2-3p ; hsa-mir-876-3p ; hsa-mir-3591-5p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-636 ; hsa-mir-3140-3p ; hsa-mir-4445-5p ; hsa-mir-508-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-299-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-219a-5p ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-4327 ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-330-3p ; hsa-mir-29a-3p ; hsa-mir-218-2-3p
Nearest miRNA
hsa-let-7g/Upstream/3214326; hsa-mir-12124/Downstream/555198;
Nearest TSS
ENST00000440867/Upstream/237432; ENST00000473938/Downstream/65855;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1854441, chr3-CpG: 49/Downstream/66224
Nearest cancer related gene
ROBO1(TSG, No orient, 0)
Upstream sequence
TTACTCACTGTGCAGAGTAGATTTAAATATCCTCTATTAAGTTACACACATTTCCAAATACTCATGCTTACTGTTGAAATAAGAAGCATAAAAACAGTCC
Downstream sequence
ACACTCTACAAAAAAAGCTAAGTACTTTCACCCAAAATTATACATAGTACATGAATACAAGGAAAATGGAATGGATTATAATAACTACATGATTACTACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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