Basic Information
VIS ID
TVIS44006448
Fusion event
HTLV-1-FAM81B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
94774973/95439269 (Hg38)
End
94774973/95439269 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
FAM81B
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-4756-3p ; hsa-mir-802
Nearest miRNA
hsa-mir-10397/Upstream/1818481; hsa-mir-103a-1/Downstream/639869;
Nearest TSS
ENST00000502646/Upstream/2469; ENST00000504763/Downstream/56210;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/153852, chr5-CpG: 61/Downstream/115434
Upstream sequence
tatatccttagatatccttaaatactggcacttttatttctataggcaagcttgctaggttaaagagtatatatatatatatatatatatatatatgtat
Downstream sequence
attttaattttataaatttcttctttaaaatgttgtagggttttacacttcgaccagcaatgtatgagaagacctttctctacattttaaccaatgatga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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