Basic Information
VIS ID
TVIS44006449
Fusion event
HTLV-1-MAN2A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
109033661/109697960 (Hg38)
End
109033661/109697960 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAN2A1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-320a ; hsa-mir-149-5p ; hsa-mir-188-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-4633-5p ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-5697 ; hsa-mir-532-5p ; hsa-mir-4521 ; hsa-mir-219b-5p ; hsa-mir-576-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-10397/Upstream/8881395; hsa-mir-103a-1/Downstream/815869;
Nearest TSS
ENST00000502646/Upstream/8594; ENST00000502261/Downstream/96215;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/6960, chr5-CpG: 24/Downstream/187325
Upstream sequence
TCAAACTTTGTGTTTTTAGAGAGTGGTTTAAAACTTGTGTTATCTACATGTTTCATAGATTTCCAGGTATCCTTGGGGAACTTTGATGCTAGAGCATCGA
Downstream sequence
CATGCTTGATGAGTTTGTTTCTCTTCTTTCACCTGAAGGTTTTGCACTGTAGGACTGCTCTGGGAAGGAAGGTTCTGGGCCATGAACTAGGCAAAATTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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