Basic Information
VIS ID
TVIS44006461
Fusion event
HTLV-1-ZNF236 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
74661533/76949577 (Hg38)
End
74661533/76949577 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF236
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-132-3p ; hsa-mir-128-3p ; hsa-let-7e-5p ; hsa-mir-4732-5p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-6783-5p ; hsa-mir-548n ; hsa-mir-6872-3p ; hsa-mir-670-3p ; hsa-mir-6836-3p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-4797-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-660-3p
Nearest miRNA
hsa-mir-1-2/Upstream/4096195;
Nearest TSS
ENST00000575820/Upstream/21650; ENST00000583326/Downstream/25113;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/29488, chr18-CpG: 17/Downstream/29729
Upstream sequence
CCAATCTGTATGAGTGAATAcaggcatacctcagagataacatgcattcagttctagagcactgcaataaagcgattatcacaacaaagtcatacattaa
Downstream sequence
cattatgatttagttttctggtttcccagggcatatgatgtttatactatactgtaataatagtgttcagcagcattatttctctttttttttttttttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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