Basic Information
VIS ID
TVIS44006472
Fusion event
HTLV-1-GGA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
38027084/37631077 (Hg38)
End
38027084/37631077 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA22A
Target gene
GGA1
miRNAs that regulate target gene
hsa-mir-320a ; hsa-mir-136-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-210-5p ; hsa-mir-4749-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-3667-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6756-3p ; hsa-mir-3127-3p
Nearest miRNA
hsa-mir-1286/Upstream/1344170; hsa-let-7a-3/Downstream/213195;
Nearest TSS
ENST00000624155/Upstream/409; ENST00000459646/Downstream/3577;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/21813, chr22-CpG: 51/Downstream/8266
Upstream sequence
CTCCAGCGCCACCAGCCTTCTCCACACCGTGTCCCCAGAGCCCCCCAGGCCTCCGCAGCAGCCCGTACCAACCGAGCTCTCACTGGCCAGCATCACTGTG
Downstream sequence
CCCCTGGAGTCCATCAAACCCAGTGAGTAGGGCTGGGGCAGGTGCAGGCTGGGTTgggtcagcttgctgccctgtcaggagctctgtctggggaagctag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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