Basic Information
VIS ID
TVIS44006475
Fusion event
HTLV-1-EYS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65259699/64549806 (Hg38)
End
65259699/64549806 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/7159594; hsa-mir-10524/Downstream/6827154;
Nearest TSS
ENST00000381078/Upstream/172011; ENST00000449928/Downstream/163529;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/913246, chr6-CpG: 22/Downstream/751554
Upstream sequence
TTACGCCTTCCTACAGCACATGAAATCTTttttttttttttttttatactttaagttttacggtacatgtgcaaaacgtgcaggtttgttacatatgtat
Downstream sequence
acatgtgccatgttggtgtgctgcacccattaactcgtcatttaacattaggtatatctcctaatgctatccctccctcctccccctaccccacaacagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate