Basic Information
VIS ID
TVIS44006477
Fusion event
HTLV-1-NBAS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
15667358/15527234 (Hg38)
End
15667358/15527234 (Hg38)
Orient
-
Location type
Intronic
Target gene
NBAS
miRNAs that regulate target gene
hsa-mir-432-5p
Nearest miRNA
hsa-mir-3125/Upstream/2789790; hsa-mir-10b/Downstream/3821195;
Nearest TSS
ENST00000437798/Upstream/15931; ENST00000438178/Downstream/34096;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/891549, chr2-CpG: 27/Downstream/33781
Upstream sequence
agaaaacaaaatagaaaaggagaaaaaaggaaaagtcaaaagaaagaaacataaaTTTTCTTTTCTACTCAAAAAATAAGAGTTACTTATTCAAGGTGTC
Downstream sequence
CTCAGAGCCAGAGCTCatatactatttgctgtgggttttacaaaggtatacagtacatattccttgccttcaagtagctgatagtctaattggagatatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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