Basic Information
VIS ID
TVIS44006490
Fusion event
HTLV-1-BTBD11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
107717597/107323820 (Hg38)
End
107717597/107323820 (Hg38)
Orient
-
Location type
Intronic
Target gene
BTBD11
Nearest miRNA
hsa-let-7i/Upstream/2732104; hsa-mir-1178/Downstream/1311990;
Nearest TSS
ENST00000382841/Upstream/3232; ENST00000494235/Downstream/256830;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/3490, chr12-CpG: 46/Downstream/257245
Upstream sequence
CAAGAATGAGTTGGTCTTCCTGGCTTCCTTGTGAGGGCTTCCTTGATGCAACCCCTTCTCCATtcttattcatctctgtgtctccttccatatcactcag
Downstream sequence
cacagtgcctggcactttgtataacagatactctctactgcttgttaaacgaatATAACCAGCTCATTCAATTTTAGGCATTTAAAATTTGCCTATCACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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