Basic Information
VIS ID
TVIS44006502
Fusion event
HTLV-1-THOC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
238976/238976 (Hg38)
End
238976/238976 (Hg38)
Orient
+
Location type
Intronic
Target gene
THOC1
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-8078/Upstream/126637; hsa-mir-1-2/Downstream/3646377;
Nearest TSS
ENST00000575820/Upstream/12574; ENST00000581677/Downstream/6758;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/79665, chr18-CpG: 61/Downstream/28734
Upstream sequence
TTGAAAGTTTTCAGTTTAAAAGATGACTTTATGACTTTTCTTTGATTAAACCACAAGGTAGAAAAAAGATACAAATATAGAATTTTAATAAACATAAGAC
Downstream sequence
TTTTCTACCTTTAAAAGGCTAAAATGAAACTTTCTAATTAACATTGGTTATTTTGTTGTTACCTCTATTATTAACTCAGGATTATTTACACATAAACATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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