Basic Information
VIS ID
TVIS44006511
Fusion event
HTLV-1-SRGAP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
9240387/9198703 (Hg38)
End
9240387/9198703 (Hg38)
Orient
-
Location type
Intronic
Target gene
SRGAP3
Nearest miRNA
hsa-mir-4790/Upstream/3948448; hsa-let-7g/Downstream/1081648;
Nearest TSS
ENST00000440867/Upstream/6168; ENST00000432981/Downstream/18057;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/62198, chr3-CpG: 27/Downstream/164296
Nearest cancer related gene
SRGAP3(TSG, No orient, 0)
Upstream sequence
tccagtcctgAGCAAccactgtttaattgtaagctccatgaaggcaaagaccatgtctgtctactcccagcacctggcattgtgtctagcacaggatgaa
Downstream sequence
tacgtcaataggtgCAAGGAAGAGGTTGCAGGGCCCAGAGGCCTTGTCCTTTCTCTCCCCAGCAAACGGGGCTAGGACTGTCCTTTCTTCTAAAGGGCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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