Basic Information
VIS ID
TVIS44006552
Fusion event
HTLV-1-HHAT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
210600480/210427136 (Hg38)
End
210600480/210427136 (Hg38)
Orient
+
Location type
Intronic
Target gene
HHAT
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-122-5p ; hsa-mir-10b-5p ; hsa-let-7c-5p ; hsa-mir-6818-3p ; hsa-mir-6873-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-3189-5p ; hsa-mir-7160-5p ; hsa-mir-8077 ; hsa-mir-4663 ; hsa-mir-93-3p
Nearest miRNA
hsa-mir-101-1/Upstream/803626; hsa-mir-1182/Downstream/1650477;
Nearest TSS
ENST00000473358/Upstream/57421; ENST00000367009/Downstream/12447;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/97687, chr1-CpG: 16/Downstream/256581
Upstream sequence
gaattcagttcttttcctggttcagtcttcggagggtgtatgtgtcctggaaatgataactttcttctagattttctagtttgacatattaataatattc
Downstream sequence
tctgatggttgtttgtaattctgtggggtcagtggtaatatcccccttgtttcttattgtgttcatttgaatcttctctctttattagtctagttagtgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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