Basic Information
VIS ID
TVIS44006564
Fusion event
HTLV-1-KCNMA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
78843090/77083332 (Hg38)
End
78843090/77083332 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
KCNMA1
miRNAs that regulate target gene
hsa-mir-211-5p ; hsa-mir-218-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1265/Upstream/1530779; hsa-mir-107/Downstream/9181362;
Nearest TSS
ENST00000439456/Upstream/3620; ENST00000428936/Downstream/7390;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/970785, chr10-CpG: 220/Downstream/553005
Upstream sequence
CTGCAATTTATGCTACAGAAAAGACAAATTCCAAAGGGCCTCTAACTACCTGGAGCAAAATACCTTGACTTTTTAGTCATTTCATTGTCACACAATGTGA
Downstream sequence
CTACTGGGTTTATGCAAGGAACAAAAACTGAACAATTGCTTTTTTTCTGAATTAAGAAAAGAATAAGGTGCTGGTGTTGGGGCCAATATTAGCAGTTGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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