Basic Information
VIS ID
TVIS44006574
Fusion event
HTLV-1-OSBP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59345891/59578418 (Hg38)
End
59345891/59578418 (Hg38)
Orient
-
Location type
Intronic
Target gene
OSBP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-505-3p ; hsa-mir-365a-3p ; hsa-mir-6878-5p ; hsa-mir-2467-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-5197-3p ; hsa-mir-6507-5p ; hsa-mir-3157-5p ; hsa-mir-4671-3p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-6077 ; hsa-mir-6770-5p ; hsa-mir-3179 ; hsa-mir-1252-5p ; hsa-mir-4691-3p ; hsa-mir-203a-3p ; hsa-mir-7852-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-3154 ; hsa-mir-5680 ; hsa-mir-4422 ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-129-2/Upstream/1937132; hsa-let-7a-2/Downstream/16659;
Nearest TSS
ENST00000527297/Upstream/12344; ENST00000531108/Downstream/22174;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/17384, chr11-CpG: 68/Downstream/37021
Upstream sequence
TTCCCCCGTCACCTGCAAGGGTGGAGAACAGGGCTTGGCTATATAGAATTCACTGTGAATTAGCTTACCTGACTATACTGGAAGTCCTAGGATAAATAAT
Downstream sequence
GGTTAGGTCCTGTTATAACAAACACCAGAGAGTCATCCAAATTATTATTAgagatgggatcttgctctgttgcccaggctggagtacactgatgcaatcg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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