Basic Information
VIS ID
TVIS44006584
Fusion event
HTLV-1-KIF21A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
39823122/39429320 (Hg38)
End
39823122/39429320 (Hg38)
Orient
-
Location type
Intronic
Target gene
KIF21A
miRNAs that regulate target gene
hsa-mir-140-3p ; hsa-mir-186-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-145-5p ; hsa-mir-195-5p ; hsa-mir-539-5p ; hsa-mir-432-5p ; hsa-mir-3156-3p ; hsa-mir-4446-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-3682-3p ; hsa-mir-188-3p ; hsa-mir-1224-3p ; hsa-mir-1245b-3p ; hsa-mir-7705 ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-5683
Nearest miRNA
hsa-mir-1244-3/Upstream/13555241; hsa-let-7i/Downstream/2894380;
Nearest TSS
ENST00000382841/Upstream/61393; ENST00000405531/Downstream/13623;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/283622, chr12-CpG: 120/Downstream/13089
Upstream sequence
AAAAGGAATGAATTTCCATTAACACACATACCAACAGAGAACAAAGATTAAGAAAACATTTTATTCAAACTGCTCTAGGGGGTTTAATCATCTCAGTCTT
Downstream sequence
AACTTTCACAACTCAACATATTCATTAAAGATAATTCAAGATATCCATTCTATCATATAAATACAATGCTAATAGCTTTGACTGGTAATATCAAGGTCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate