Basic Information
VIS ID
TVIS44006591
Fusion event
HTLV-1-MZT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
73282535/72708397 (Hg38)
End
73282535/72708397 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA13B
Target gene
MZT1
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-93-5p ; hsa-mir-4282 ; hsa-mir-1-5p ; hsa-mir-590-3p ; hsa-mir-548c-3p ; hsa-mir-6507-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-31-5p ; hsa-mir-4424 ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-5186 ; hsa-mir-4307 ; hsa-mir-586
Nearest miRNA
hsa-mir-1297/Upstream/6490073; hsa-mir-1267/Downstream/4989615;
Nearest TSS
ENST00000623511/Upstream/841205; ENST00000618209/Downstream/19290;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/840753, chr13-CpG: 91/Downstream/18695
Upstream sequence
tatcttttGTCCTATAGAAACACAAGTTGAATTAACAAAAGCATATATTAAAACAAAAGTACAGGCCAATACCACCAAAATGGTTTTATTTTTGTCATTG
Downstream sequence
ACAACAAGCACAACACTGCAATTGTATCATTATTTTGTTTAGTTTCTTAAATATTACTTAAGTATGCATTAAAAATATGTTTACATTTTAAAAATGTGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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