Basic Information
VIS ID
TVIS44006596
Fusion event
HTLV-1-PCID2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
113846628/113192314 (Hg38)
End
113846628/113192314 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCID2
miRNAs that regulate target gene
hsa-mir-93-5p
Nearest miRNA
hsa-mir-1267/Upstream/2851285; hsa-mir-4502/Downstream/70606;
Nearest TSS
ENST00000623511/Upstream/3706; ENST00000474116/Downstream/8359;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/37845, chr13-CpG: 236/Downstream/15734
Upstream sequence
ttgcacttcagcttgggtgacagagcaagaccatctctaaataaataaataaaatgtccttgataatgcagtaaatatgaattttcttaaatcttggtcc
Downstream sequence
ttgagcacacgttttttatattctttgtgatgaaatgagaagcatacagcacttctgttgcacacgggtgtctcatggctgtttacagaaaagctctggg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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