Basic Information
VIS ID
TVIS44006605
Fusion event
HTLV-1-chr14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68072097/67605380 (Hg38)
End
68072097/67605380 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
GPHN ; LOC105370543
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-375
Nearest miRNA
hsa-mir-208a/Upstream/163450; hsa-mir-1185-1/Downstream/4911440;
Nearest TSS
ENST00000550708/Upstream/5093; ENST00000556491/Downstream/14418;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/4963, chr14-CpG: 62/Downstream/14180
Nearby gene
PIGH(-5080) ;
Upstream sequence
cctcatttgtaggtatttgatgttttctgatattctcataaatgatgtACATTAAAAATTTATTAACTCTCCCtttttatttatttatttttagagacac
Downstream sequence
catctcactctgtcacccaggctagagtccattggcacaaatatcagctcactataacttcaaattcctgggctcaaggtattctcccaccttggcctcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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