Basic Information
VIS ID
TVIS44006614
Fusion event
HTLV-1-chr15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
61743481/61451282 (Hg38)
End
61743481/61451282 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA15A
Nearest miRNA
hsa-mir-10393/Upstream/2280020; hsa-mir-11181/Downstream/853376;
Nearest TSS
ENST00000557528/Upstream/211376; ENST00000561182/Downstream/147232;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/221765, chr15-CpG: 83/Downstream/608746
Nearby gene
RORA(-221979) ;
Upstream sequence
ctcggtctcccaaagtgttgggattacaggcgtgagccaccacgcccagccCTGAATTGAATTTCAACTGAATTCGAGCCTGACAAGTTAATCGAACTAG
Downstream sequence
TTATAGCTTAAGTAAAATTATTCTAGTGAGCACTGTCCTTGAATTTTTTTGAATTGACAAAATTTATATTACTGACCTGAATTTTCAAGTTGCTCAGGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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