Basic Information
VIS ID
TVIS44006621
Fusion event
HTLV-1-CHSY1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
101780574/101240369 (Hg38)
End
101780574/101240369 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHSY1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-375 ; hsa-mir-9-5p ; hsa-mir-221-3p ; hsa-mir-6807-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-655-5p ; hsa-mir-4795-5p ; hsa-mir-7113-5p ; hsa-mir-9500 ; hsa-mir-6753-5p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-7641 ; hsa-mir-4477a ; hsa-mir-570-3p ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-3200-5p ; hsa-mir-5582-5p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-506-3p ; hsa-mir-5096 ; hsa-mir-7150 ; hsa-mir-197-3p ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-5093 ; hsa-mir-1207-5p ; hsa-mir-657 ; hsa-mir-5197-5p ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-10393/Upstream/2455867; hsa-mir-1302-10/Downstream/720090;
Nearest TSS
ENST00000557528/Upstream/5222; ENST00000558838/Downstream/2248;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/151116, chr15-CpG: 218/Downstream/10577
Upstream sequence
CCACCATCCTGAGGAGGAGGAGGGGATGCATTAATAATTTCAAATAATTGAAGGGAATGCTCCCAAAGAAGCAAGCTGTCCCCTCTTCTGCAATATCAAC
Downstream sequence
AAgtccagttccttcattttcataagcaaacgtcagctttgccatcaacacatttgttaccgggagcaaagaactctcacttaattgaaatgacaaaacg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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