Basic Information
VIS ID
TVIS44006631
Fusion event
HTLV-1-STXBP4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
53087943/55010582 (Hg38)
End
53087943/55010582 (Hg38)
Orient
-
Location type
Intronic
Target gene
STXBP4
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-7702 ; hsa-mir-151a-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-4448 ; hsa-mir-3670 ; hsa-mir-556-5p
Nearest miRNA
hsa-mir-10226/Upstream/4241852; hsa-mir-1250/Downstream/1880688;
Nearest TSS
ENST00000595228/Upstream/10766; ENST00000468837/Downstream/20225;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/41575, chr17-CpG: 65/Downstream/227675
Upstream sequence
TTATTTGTAGTGATATATTTCTTCAAAGTATGAATAGTATATGTCTCATTTGATCCTAATATTAAACTTATAAATATGCATTATAAACTTAGCAAATAGG
Downstream sequence
GATACAATTTATTGCTTGGCTTGAAATCAAAATATCGTACCTCTGCATTATCTGTATATTTATACCTATGGAAGATGCTTTGGGATATGGATGCCATTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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