Basic Information
VIS ID
TVIS44006633
Fusion event
HTLV-1-STRADA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
61780489/63703129 (Hg38)
End
61780489/63703129 (Hg38)
Orient
-
Location type
UTR3
Target gene
STRADA
Nearest miRNA
hsa-mir-10226/Upstream/758817; hsa-mir-1250/Downstream/797645;
Nearest TSS
ENST00000595228/Upstream/1957; ENST00000581135/Downstream/1326;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1756, chr17-CpG: 60/Downstream/38195
Nearest cancer related gene
STRADA(TSG, No orient, 0)
Upstream sequence
GTCAGGGCCCAAGCCAGAAGAGGGATAAGGATGGACTGTTCCAGCCTTAGTCTGTGCTTAAAAAGACAGAAATGCCCTTCTCTGGAATTATGAGGGAGAG
Downstream sequence
GTCTGAGGGAAGGGAGGCAGGCAGCTTACTACTTGCCCTTTCACTGACCTATAGCATCTGAGGCATCTGAGAGCAAAGTTAAATAGAATGAGGCTGGTCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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