Basic Information
VIS ID
TVIS44006637
Fusion event
HTLV-1-ZNF675 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
23862428/23679626 (Hg38)
End
23862428/23679626 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF675
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4279 ; hsa-mir-4502 ; hsa-mir-3921 ; hsa-mir-4653-5p ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p ; hsa-mir-3675-3p ; hsa-mir-3927-5p ; hsa-mir-5694 ; hsa-mir-5571-5p ; hsa-mir-365b-3p ; hsa-mir-5583-5p ; hsa-mir-365a-3p ; hsa-mir-3129-3p ; hsa-mir-629-3p ; hsa-mir-183-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4703-3p ; hsa-mir-600 ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4712-5p ; hsa-mir-770-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-4653-3p ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-6514-5p
Nearest miRNA
hsa-mir-10395/Upstream/3280272; hsa-let-7e/Downstream/11443074;
Nearest TSS
ENST00000633603/Upstream/22492; ENST00000531821/Downstream/6755;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/208184, chr19-CpG: 21/Downstream/78812
Upstream sequence
gggatctaactgaagagtttcttcatagaaaactattaacagagtaaagacaacctacagaataaaagaaaatatttgcaaactatgcttttgacaaagg
Downstream sequence
tctaatatccagaatccataatgaacttaaataagtttacaagaaaaaaaaaaaaacctcattaaaaagtaggTGGCCAGGCACCACAACCTACTTgctc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate